I started using progesterone cream after I ovulated and after 15 months of trying we have done it. So it worked first cycle for us.
If you use it before you ovulate you can prevent ovulation from occurring though,so you need to track ovulation if you decide to use it.
I had exceptionally high oestrogen levels on blood tests and despite recovering a normal level my progesterone never sorted itself out.
I found the cream to be excellent for removing the mid cycle irritability I suffer, so I could tell instantly that I needed it.
Soya is the worst thing to have, it increases oestrogen in your system and makes your progesterone ratio even poorer.