How does IVF work...

soffphie

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I havent ever been brave enough to visit and clinic and actually sit down and ask!..
but.. how does IVF work.
my understanding.. you get given drugs to remove as many eggs as possible, these are fertilised, say for example 7 are good. what happens with all them good eggs? how does it work? does 1 cycle cover all 7 eggs being transfered one after another if each egg fails?
and excuse my ignorance but how does IVF fail?

Thank you so much for any feedback!
 
My understanding is that you are given drugs initially to stimulate egg supply, the eggs are collected using a needle into each ovary. These are then mixed with sperm in a lab and left to see if any fertilise. Any that fertilise are then grown in a lab for several days before they are graded and the best 1/2 are transferred. I think the decision to transfer 1 or 2 depends on the quality.

Any embryos not transferred can be frozen for use at a later date. I think the NHS classes each transfer as a cycle.
 
As described above it sounds about right but if you’re paying privately a cycle is classed as per egg retrieval so if you get 6 eggs retrieved and 4 fertilise then those 4 egg transfers are classed as 1 cycle (especially for payment terms too). Sometimes though you may have 6 eggs retrieved but only 1 fertilises so literally all your eggs are in that 1 basket haha
 
in simple terms you're right. here's a slightly longer version.

there are two types of IVF, long course and short course. depending on why you need IVF will depend on which course you start on and what dose of drugs you're on.

the long course you will start something called a down reg before you start stimulation. this will switch off your natural hormones so that the hospital/clinic are in complete control of your cycle. short course you go straight to stimulation missing the down reg, this is normally the course picked for women who they worry will over stimulate and could end up with OHSS. even though it sounds great being over stimulated and having tons of eggs, it is actually very unhealthy and can be quite dangerous.

once you start your stims you will be scanned every few days. this will check how many follicles you have and the size of them. most clinics look for follicles of 16mm or bigger before they will try for collection but they can works with smaller, so its not always a huge factor. so the stims can last anything from 7 days to two weeks, depending upon how quickly your body responds to the stims (personally my first round look 15 days, second was 9 as I was on short course)

note - each stims is different for each woman, I had injections that I had to administer at home. for the first 5 days I had one lot of drugs and then on day 6 I started a second drug, so I ended up having one injection in the morning and one in the evening. but each woman is different and different courses use different drugs, so this isn't guaranteed.

on egg collection day you will be put under a general anesthetic where via ultra sound, they will guide a needle to your ovaries via your vagina (they will pierce your vaginal wall in order to get to your ovaries - its not painful but you can be a bit swollen for a few days afterwards). they will puncture your follicles and drain them of the fluid inside - which can contain eggs (its not a guarantee that a follicle will contain an egg, so it could be empty) the hospital/clinic will tell you on the day how many eggs they were able to get. but they will not be able to tell you quality at this stage - quality is only discussed at transfer stage.

once all your follicles have been emptied, an embryologist will take the liquid straight to the lab and start going through it to look for your eggs. after this it depends upon whether you're having standard IVF or ICSI (ICSI is normally used when the sperm are not top quality or they believe the sperm may have a difficult time penetrating the egg). with standard IVF your eggs will be mixed with your partners sperm in a dish and left on their own to fertilize. ICSI your partners sperm will be cleaned and a single sperm will be chosen and injected straight into the egg.

after this your clinic will be in touch within 24 hours to let you know how many from your original number have fertilized. its not a guarantee that if you get 7 eggs, all will fertilize, so the more eggs you get, the better your chances are of one of them fertilizing.

after this, your hospital/clinic will try to go for a day 5 transfer once your embryo has become a blastocyst. hospitals can put your embryos back in sooner if they feel that it would do better inside your body (my first round went back in on day 2 - I only had 3 eggs and only 1 fertilized. on my second attempt I had 15 eggs, 12 fertilized but only 5 were of decent quality to work with. I had 1 day 5 embryo transferred and 4 put into the freezer)

after that, once your embryo is back in, its the dreaded two week wait where you will slowly lose your mind haha

with regards to how they work out a cycle, my hospital classed 1 cycle as everything up to 1 fresh transfer (so a day 5 embryo that had not been frozen) any frozen embryos that we want to use we will have to pay a fee to use. each hospital and clinic are different, so that will depend on where you go.

with regards as to why IVF doesn't work.... that's a hard question. I have no idea why my first round failed and neither did my consultant. I know women who had top quality embryos put in and had such a healthy lifestyle and did everything right and for what ever reason, it just didn't work. but I know of women the other way round who had slightly worse quality embryos and now have bouncing babies. there is only ever a 40% chance that a embryo will take regardless of quality (according to my consultant)

I hope this answers your questions. IVF seems daunting but I always feel that the more you know, the better prepared you are for whats about to happen. my first time I felt worried because I didn't understand the lingo and process, second time I was a lot more relaxed. so don't be scared to visit a clinic and discuss your options, you'll feel better for knowing what's happening and what you can do.
 
in simple terms you're right. here's a slightly longer version.

there are two types of IVF, long course and short course. depending on why you need IVF will depend on which course you start on and what dose of drugs you're on.

the long course you will start something called a down reg before you start stimulation. this will switch off your natural hormones so that the hospital/clinic are in complete control of your cycle. short course you go straight to stimulation missing the down reg, this is normally the course picked for women who they worry will over stimulate and could end up with OHSS. even though it sounds great being over stimulated and having tons of eggs, it is actually very unhealthy and can be quite dangerous.

once you start your stims you will be scanned every few days. this will check how many follicles you have and the size of them. most clinics look for follicles of 16mm or bigger before they will try for collection but they can works with smaller, so its not always a huge factor. so the stims can last anything from 7 days to two weeks, depending upon how quickly your body responds to the stims (personally my first round look 15 days, second was 9 as I was on short course)

note - each stims is different for each woman, I had injections that I had to administer at home. for the first 5 days I had one lot of drugs and then on day 6 I started a second drug, so I ended up having one injection in the morning and one in the evening. but each woman is different and different courses use different drugs, so this isn't guaranteed.

on egg collection day you will be put under a general anesthetic where via ultra sound, they will guide a needle to your ovaries via your vagina (they will pierce your vaginal wall in order to get to your ovaries - its not painful but you can be a bit swollen for a few days afterwards). they will puncture your follicles and drain them of the fluid inside - which can contain eggs (its not a guarantee that a follicle will contain an egg, so it could be empty) the hospital/clinic will tell you on the day how many eggs they were able to get. but they will not be able to tell you quality at this stage - quality is only discussed at transfer stage.

once all your follicles have been emptied, an embryologist will take the liquid straight to the lab and start going through it to look for your eggs. after this it depends upon whether you're having standard IVF or ICSI (ICSI is normally used when the sperm are not top quality or they believe the sperm may have a difficult time penetrating the egg). with standard IVF your eggs will be mixed with your partners sperm in a dish and left on their own to fertilize. ICSI your partners sperm will be cleaned and a single sperm will be chosen and injected straight into the egg.

after this your clinic will be in touch within 24 hours to let you know how many from your original number have fertilized. its not a guarantee that if you get 7 eggs, all will fertilize, so the more eggs you get, the better your chances are of one of them fertilizing.

after this, your hospital/clinic will try to go for a day 5 transfer once your embryo has become a blastocyst. hospitals can put your embryos back in sooner if they feel that it would do better inside your body (my first round went back in on day 2 - I only had 3 eggs and only 1 fertilized. on my second attempt I had 15 eggs, 12 fertilized but only 5 were of decent quality to work with. I had 1 day 5 embryo transferred and 4 put into the freezer)

after that, once your embryo is back in, its the dreaded two week wait where you will slowly lose your mind haha

with regards to how they work out a cycle, my hospital classed 1 cycle as everything up to 1 fresh transfer (so a day 5 embryo that had not been frozen) any frozen embryos that we want to use we will have to pay a fee to use. each hospital and clinic are different, so that will depend on where you go.

with regards as to why IVF doesn't work.... that's a hard question. I have no idea why my first round failed and neither did my consultant. I know women who had top quality embryos put in and had such a healthy lifestyle and did everything right and for what ever reason, it just didn't work. but I know of women the other way round who had slightly worse quality embryos and now have bouncing babies. there is only ever a 40% chance that a embryo will take regardless of quality (according to my consultant)

I hope this answers your questions. IVF seems daunting but I always feel that the more you know, the better prepared you are for whats about to happen. my first time I felt worried because I didn't understand the lingo and process, second time I was a lot more relaxed. so don't be scared to visit a clinic and discuss your options, you'll feel better for knowing what's happening and what you can do.

wow, thank you for taking time to write such a detailed message.
It is interesting that some will class 1 cycle as all good eggs, and others not.. i suppose thats why you shop around first (we have 3 we could potentially use), im still at testing stage thankfully! but i can see this coming up middle of the year sadly.
 
As described above it sounds about right but if you’re paying privately a cycle is classed as per egg retrieval so if you get 6 eggs retrieved and 4 fertilise then those 4 egg transfers are classed as 1 cycle (especially for payment terms too). Sometimes though you may have 6 eggs retrieved but only 1 fertilises so literally all your eggs are in that 1 basket haha

so if im right, if you do pay privately and say get 4 good eggs, choose to only transfer 1 but that 1 fails for the same cycle/same price you could in theory keep transfering until all eggs are gone?
 
so if im right, if you do pay privately and say get 4 good eggs, choose to only transfer 1 but that 1 fails for the same cycle/same price you could in theory keep transfering until all eggs are gone?
Yes that’s it :-)
 
My clinic includes the storing of frozen eggs for 1 year in the first cycle but if you want to use them in future cycles it’s £900 per transfer.

If you don’t have any to freeze after first cycle you have to go through the whole process from scratch again, so another £4-6k.
 
My clinic includes the storing of frozen eggs for 1 year in the first cycle but if you want to use them in future cycles it’s £900 per transfer.

If you don’t have any to freeze after first cycle you have to go through the whole process from scratch again, so another £4-6k.

so your clinic only allow you one transfer for the £5k you paid?
 
so your clinic only allow you one transfer for the £5k you paid?

Yes. One transfer then extra £900 for any transfers with frozen eggs. Believe it or not we were quite relieved at that as initially thought it was £6k every time. It all feels very complicated and overwhelming but once you start it feels more practical.

We shopped around and the 3 clinics near us were all similar prices x
 
Yes. One transfer then extra £900 for any transfers with frozen eggs. Believe it or not we were quite relieved at that as initially thought it was £6k every time. It all feels very complicated and overwhelming but once you start it feels more practical.

We shopped around and the 3 clinics near us were all similar prices x
I think that price is pretty standard.

I know some clinics will transfer 2 eggs at the same time but it depends on circumstances and the clinic.
 
so when people say it took 2 rounds of IVF;
do they mean it took many transfers so
round 1 is 7 fertilised eggs, 1 transfer
round 2 is now 6 fertilited eggs left after a 2nd transfer etc etc...
sorry if i sound super stupid!
 
You’re not stupid hunny, it’s confusing.

Round 1 you start from scratch so they can get the eggs. They could get 10 eggs but only 6 fertilise and then the eggs need to survive and develop to 3 or 5 days. They then pick the best one to transfer. Any spare can get frozen.

Round 2 If you’ve no frozen eggs to use you start from scratch. OR

Round 2 - you use one of your frozen eggs and whilst you’ll still need drugs it won’t be as long a process.

IVF can stop at any point though. I finish my STIMS today and as I’m older I’ve got 8 follicles. At Egg Collection on Monday they might discover more that the scan didn’t see, or I could be unlucky and some follicles have no egg.
Then it could be that only 2 fertilise and the quality is rubbish and we don’t get as far as transfer. Or we could be lucky and all fertilise and some are great quality.
It’s a rollercoaster.

Have you thought about going along to an open day? They’ll explain things and there’s no pressure to buy. It gives you a feel for the staff which really is important and you need to have faith in them x
 
You’re not stupid hunny, it’s confusing.

Round 1 you start from scratch so they can get the eggs. They could get 10 eggs but only 6 fertilise and then the eggs need to survive and develop to 3 or 5 days. They then pick the best one to transfer. Any spare can get frozen.

Round 2 If you’ve no frozen eggs to use you start from scratch. OR

Round 2 - you use one of your frozen eggs and whilst you’ll still need drugs it won’t be as long a process.

IVF can stop at any point though. I finish my STIMS today and as I’m older I’ve got 8 follicles. At Egg Collection on Monday they might discover more that the scan didn’t see, or I could be unlucky and some follicles have no egg.
Then it could be that only 2 fertilise and the quality is rubbish and we don’t get as far as transfer. Or we could be lucky and all fertilise and some are great quality.
It’s a rollercoaster.

Have you thought about going along to an open day? They’ll explain things and there’s no pressure to buy. It gives you a feel for the staff which really is important and you need to have faith in them x

There arent any open days at present being advertised. And im really not brave! I keep saying right i must now get this testing done privately as i must know now! Then i chicken out & dont book them etc...
Got to wait for sperm results and wait for nhs proposed next step. Ideally all testing be done by May
 

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