Honey if Metanium isn't helping then you might need Canesten or possibly an equivalent with a bit of steoroid in it, but you need t see a doctor for it... Sweetie are you sure you are using yellow Metanium or a regular one? I m just checking cause a yellow one always helps my little one... Apart from that he best advise I can give is don't wipe with cotton wool or anything , I just pick my lo up and stick her bum under the running water and clean it this way, this way it's totally pain free for them cause when they get a bad rash ( and mine just had a case of that ) any wiping/rubbing is painful. Just let nice warm emperature water run and put his bum and front under it and clean him up. Then I just dab with a very soft towel. And my main remedy is loads and loads of nappy free time hun. Good luck , I know how hard this can be...